Association Between Comorbidities and Activity Level (K-Level) in Patients with Lower-Limb Amputation
DOI:
https://doi.org/10.25759/spmfr.530Abstract
Lower limb amputations are a common condition associated with functional limitations and a significant impact on quality of life. The decision to provide or not provide prostheses to these patients is complex, requiring specialized evaluation. Currently, there are no universally accepted and validated criteria to guide prosthetic candidacy, making this process frequently complex and challenging. The functional classification system of activity levels (K-level) is one of the tools commonly used to support this decision, although it does not systematically take into account other relevant factors such as associated comorbidities. The aim of this study was to determine whether there is a relationship between the comorbidities of patients with lower limb amputations and the activity level (K level) assigned by a rehabilitation medicine specialist.
Methods: This is a retrospective observational study including 116 patients admitted to a first consultation for amputee rehabilitation between January 2022 and December 2023.
Results: Statistically significant relationships (p < 0.05) and strong associations (Cramer's V ≥ 0.50) were found between K-Level and comorbidities such as stroke and peripheral vascular disease (PVD). In subgroup analysis, a strong association was observed between K-Level and the comorbidities PVD and diabetes, both more prevalent in lower K-Levels. Conditions such as myocardial infarction, diabetes, chronic kidney disease, hypertension, and dyslipidemia also showed significant association, though considered moderate. On the other hand, chronic obstructive pulmonary disease, heart failure, and smoking were not associated with K-Level.
Conclusion: Patients with lower K levels (K0 and K1) exhibit a significantly higher number of comorbidities when compared to patients with higher K levels (K2 and K3). The comorbidities stroke, diabetes mellitus, and peripheral artery disease are associated with lower K levels.
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References
Varma P, Stineman MG, Dillingham TR. Epidemiology of limb loss. Phys Med Rehabil Clin N Am. 2014;25(1):1–8.
Romano J, Caria N, Cavalheiro A, Cunha M, Cantista P. Characterization of a Portuguese major amputee population: 5 years of a Physical and Rehabilitation Medicine amputee unit. Rev SPMFR. 2025;53(1):9–12.
Matos JP, Carolino E, Ramos R. Epidemiological data on amputations performed in Portugal between 2000 and 2015. In: Lisbon: Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa; 2018.
Varma P, Stineman MG, Dillingham TR. Epidemiology of limb loss. Phys Med Rehabil Clin N Am. 2014;25(1):1–8.
Sinha R, van den Heuvel WJA, Arokiasamy P. Factors affecting quality of life in lower limb amputees. Prosthet Orthot Int. 2011;35(1):90-6.
Hamamura S, Chin T, Kuroda R, Akisue T, Iguchi T, Kohno H, et al. Factors affecting prosthetic rehabilitation outcomes in amputees aged 60 years and over. J Int Med Res. 2009;37(6):1921-7.
Vaz MI, Roque V, Pimentel S, Rocha A, Duro H. Psychosocial characterization of a Portuguese lower limb amputee population. Acta Med Port. 2012. Available from: www.actamedicaportuguesa.com
Kahle JT, Highsmith MJ, Schaepper H, Johannesson A, Orendurff MS, Kaufman KR. Predicting walking ability following lower limb amputation. Technol Innov. 2016;18:125-37.
American Orthotic and Prosthetic Association (AOPA). Lower limb prosthetic workgroup consensus document. 2017 Sep.
Gailey RS, Roach KE, Applegate EB, Cho B, Cunniffe B, Licht S, et al. The amputee mobility predictor: an instrument to assess determinants of the lower-limb amputee's ability to ambulate. Arch Phys Med Rehabil. 2002;83(5):613-27.
Borrenpohl D, Kaluf B, Major MJ. Survey of U.S. practitioners on the validity of the Medicare Functional Classification Level system and utility of clinical outcome measures for aiding K-level assignment. Arch Phys Med Rehabil. 2016;97(7):1053-63.
Hamamura S, Chin T, Kuroda R, Akisue T, Iguchi T, Kohno H, et al. Factors affecting prosthetic rehabilitation outcomes in amputees aged 60 years and over. J Int Med Res. 2009;37(6):1921-7.
Kahle JT, Highsmith MJ, Schaepper H, Johannesson A, Orendurff MS, Kaufman KR. Predicting walking ability following lower limb amputation. Technol Innov. 2016;18:125-37.
Chin T, Kuroda R, Akisue T, Iguchi T, Kurosaka M. Energy consumption during prosthetic walking and physical fitness in older hip disarticulation amputees. J Rehabil Res Dev. 2012;49(8):1255-60.
Wurdeman SR, Stevens PM, Campbell JH. Mobility Analysis of AmpuTees II: comorbidities and mobility in lower limb prosthesis users. Am J Phys Med Rehabil. 2018;97(11):782-8.
Webster JB, Hakimi KN, Williams RM, Turner AP, Norvell DC, Czerniecki JM. Prosthetic fitting, use, and satisfaction following lower-limb amputation: a prospective study. J Rehabil Res Dev. 2012;49(10):1493-504.
Chamlian TR. Use of prostheses in lower limb amputee patients due to peripheral arterial disease. Einstein (Sao Paulo). 2014;12(4):440-6.
Sinha R, van den Heuvel WJA, Arokiasamy P. Factors affecting quality of life in lower limb amputees. Prosthet Orthot Int. 2011;35(1):90-6.
Wurdeman SR, Stevens PM, Campbell JH. Mobility Analysis of AmpuTees II: comorbidities and mobility in lower limb prosthesis users. Am J Phys Med Rehabil. 2018;97(11):782-8.
Webster JB, Hakimi KN, Williams RM, Turner AP, Norvell DC, Czerniecki JM. Prosthetic fitting, use, and satisfaction following lower-limb amputation: a prospective study. J Rehabil Res Dev. 2012;49(10):1493-504.
Schutze W, Gable D, Ogola G, Yasin T, Madhukar N, Kamma B, et al. Sex, age, and other barriers for prosthetic referral following amputation and the impact on survival. J Vasc Surg. 2021;74(5):1659-67. https://doi.org/10.1016/j.jvs.2021.05.025
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